Genes are the biggest factor in the cause of Autism Spectrum Disorder. One recent study reported that the liability of ASD is mostly attributed to common variations in the genetic architecture, and that rare de novo mutations contribute to individual liability (49% of common inherited variants, 3% of de novo, 3% of rare inherited variants, and 41% of unaccounted).
There are different types of genetic mutations responsible for ASD:.
Gamma-aminobutyric acid (GABA) A receptor, beta 3 (GABRB3)-which is localized to chromosome 15q11-q13 and is involved in genome instability, gene expression, imprinting and recombination, was investigated in the first era of ASD genetic research. This region became a major subject of attention because deletion of this locus is related to monogenic causes of ASD.
oxytocin receptor (OXTR)
reelin (RELN)
serotonin transporter (SLC6A4)
N-methyl-D-aspartate receptor (NMDA; GRIN2B)
arginine vasopressin receptor 1A (AVPR1A)
engrailed homeobox 2 (EN2)
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61; ITGB3)
met proto-oncogene (hepatocyte growth factor receptor; MET).
Yoo, H. (2015, December). Genetics of Autism Spectrum Disorder: Current Status and Possible Clinical Applications. Retrieved April 20, 2017, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688327/
There are different types of genetic mutations responsible for ASD:.
Gamma-aminobutyric acid (GABA) A receptor, beta 3 (GABRB3)-which is localized to chromosome 15q11-q13 and is involved in genome instability, gene expression, imprinting and recombination, was investigated in the first era of ASD genetic research. This region became a major subject of attention because deletion of this locus is related to monogenic causes of ASD.
oxytocin receptor (OXTR)
reelin (RELN)
serotonin transporter (SLC6A4)
N-methyl-D-aspartate receptor (NMDA; GRIN2B)
arginine vasopressin receptor 1A (AVPR1A)
engrailed homeobox 2 (EN2)
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61; ITGB3)
met proto-oncogene (hepatocyte growth factor receptor; MET).
Yoo, H. (2015, December). Genetics of Autism Spectrum Disorder: Current Status and Possible Clinical Applications. Retrieved April 20, 2017, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688327/